系统性红斑狼疮(SLE) 在植物药杂志发表最新题为《青蒿琥酯对易患狼疮的MRL/lpr小鼠的治疗作用取决于 T 滤泡辅助细胞分化和JAK2-STAT3 信号通路的激活 》一文中，口服 ART 显着延长 MRL/lpr 小鼠的存活时间， 改善狼疮性肾炎症状，降低沉积在肾脏中的抗 dsDNA 抗 体水平，以及致病细胞因子(IL-6、IFN-γ 和 IL -21)。
ART治疗后，MRL/lpr小鼠脾脏中的T 细胞区室在Tfh 细胞数量的减少和Tfr 与滤泡调节性T细胞(Tfh) 的比率 的维持方面得到恢复。 此外，ART 显着抑制了MRL/lpr小鼠中 Jak2和Stat3 的磷酸化水平。
ART 通过抑制Tfh 细胞的分化以及改变 Jak2-Stat3 信号级联的激活状 态，对易患狼疮的 MRL/lpr 小鼠显示出治疗效果。
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