肺动脉高压(Pulmonary Hypertension) 在心血管药理学杂志发表的题为《双氢青蒿素通过抑制大鼠肺血管重构减轻肺动脉高压》一文中，在小鼠诱导肺动脉高压模型中，对比野百合碱治疗的控制组，使用50 or 100 mg/kg 双氢青蒿素显着降低平均肺动脉压、右心室横径、肺动脉内壁厚度， 增加了三尖瓣环平面收缩期偏移。
双氢青蒿素以剂量依赖性 方式抑制血小板衍生生长因子-BB 介导的肺动脉平滑肌细胞增殖和迁移。 此外，双氢青蒿素下调 β-连环蛋白水平， 同时上调轴抑制蛋白 2 (Axin2) 和糖原合酶激酶 3β (GSK- 3β) 的水平。 我们的研究结果表明，双氢青蒿素可能是肺动脉高压治疗的潜在候选者，它可能通过抑制肺血管重塑来 减轻实验性肺动脉高压。
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