肺癌(lung cancer) -在分子药品报告杂志发表的《青蒿琥酯通过调节线粒体膜电位和诱导细胞凋亡抑制肺癌细胞》一文中，在体外抑制实验中，青蒿琥酯处理4小时后的A549人肺癌细胞。
青蒿琥酯以剂量依赖性方式抑制 A549 细胞的生长，诱导细胞凋亡和细胞周期停滞，降低 Bcl-2 蛋白和线粒体膜电位的表达，增加Bax蛋白的表达。总之，青蒿琥酯通过阻止细胞周期进程显着抑制了肺癌细胞的生长，这一现象表明其 在治疗肺癌方面具有广阔的治疗潜力。
在现代中药药理研究 杂志发表的题目为《双氢青蒿素对非小细胞肺癌的抑制作用》一文中，用荟萃分析的方法分析了截止 2020 年 12 月 31 日以来所有双氢青蒿素抗肺癌的符合要求的 36 篇文献， 结果显示双氢青蒿素对非细胞肺癌、肺鳞癌、肺腺癌、大细胞肺癌, 半数最大抑制浓度为均值为 80.89 umol/L，范围为 0.23 umol/L -749.90 umol/L。
随着暴露在双氢青蒿素 24、48、 72 、96 小时后，非细胞肺癌、肺鳞癌、肺腺癌、大细胞肺癌分别为 54.80、128.70、83.70 、12.60 umol/L 。
结果显示随着暴露在双氢青蒿素时间延长，肺癌抑制率或凋亡率越高。双氢青蒿素对肺癌细胞有明显抑制作用。
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